Regulation of myotube formation by the actin-binding factor drebrin
نویسندگان
چکیده
منابع مشابه
Mapping of drebrin binding site on F-actin.
Drebrin is a filament-binding protein involved in organizing the dendritic pool of actin. Previous in vivo studies identified the actin-binding domain of drebrin (DrABD), which causes the same rearrangements in the cytoskeleton as the full-length protein. Site-directed mutagenesis, electron microscopic reconstruction, and chemical cross-linking combined with mass spectrometry analysis were empl...
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Defects in actin dynamics affect activity-dependent modulation of synaptic transmission and neuronal plasticity, and can cause cognitive impairment. A salient candidate actin-binding protein linking synaptic dysfunction to cognitive deficits is Drebrin (DBN). However, the specific mode of how DBN is regulated at the central synapse is largely unknown. In this study we identify and characterize ...
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15 صفحه اولRegulation of actin dynamics by actin-binding proteins in pollen.
A dynamic network of polymers, the actin cytoskeleton, co-ordinates numerous fundamental cellular processes. In pollen tubes, organelle movements and cytoplasmic streaming, organization of the tip zone, vesicle trafficking, and tip growth have all been linked to actin-based function. Further, during the self-incompatibility response of Papaver rhoeas, destruction of the cytoskeleton is a primar...
متن کاملFormation of thick, curving bundles of actin by drebrin A expressed in fibroblasts.
Drebrin A is a neuron-specific protein, the expression of which is regulated during development. Upon transfection of fibroblasts with drebrin A cDNA, the protein is expressed at high levels in fibroblasts and the outgrowth of highly branched, neurite-like cell processes is induced. In this report, we describe a biochemical examination of the binding of drebrin A to actin filaments. We also dem...
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ژورنال
عنوان ژورنال: Skeletal Muscle
سال: 2011
ISSN: 2044-5040
DOI: 10.1186/2044-5040-1-36